Cell Signaling Lamtor5/Hbxip (D4v4s) Rabbit mAb

Name: Cell Signaling Lamtor5/Hbxip (D4v4s) Rabbit mAb
SKU: CSIG-14633S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Lamtor5/Hbxip (D4v4s) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-14633S

MFG.PART: 14633S

UNSPSC: 41116113

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	10.5
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50, Immunohistochemistry (Paraffin): 1:800}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	LAMTOR5/HBXIP (D4V4S) Rabbit mAb recognizes endogenous levels of total LAMTOR5/HBXIP protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu55 of human LAMTOR5/HBXIP protein.
Background	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 (LAMTOR5) is an essential component of the ragulator protein complex that is encoded by the HBXIP gene (1). The ragulator complex also includes LAMTOR1/C11orf59, LAMTOR2/ROBLD3, LAMTOR3/MAPKSP1, and LAMTOR4/C7orf59 (1,2). Research studies demonstrate that the ragulator complex localizes to the lysosomal membrane and is essential for the lysosomal localization of Rag GTPases and mTORC1 as well as the subsequent activation of mTORC1 in response to amino acid signaling (1-3). Additional research studies indicate that HBXIP regulates hepatitis B virus x (HBx) protein activity and is a transcription coactivator involved in the proliferation and migration of breast cancer cells (4,5).

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