Cayman Sodium Acetate; Size- 100 Dtn (082 G)

Terbutaline is a short-acting β₂-adrenergic receptor (β₂-AR) agonist and an active metabolite of bambuterol (Item No. ).^,, It binds to β₁-, β₂-, and β₃-ARs (K_i = 31.3, 15.4, and 79.8 nM, respectively) and selectively increases adenylyl cyclase activity in CHO cell membranes expressing recombinant human β₂- or β₃- over β₁-ARs at concentrations 100-fold greater than the respective K_i values. Terbutaline inhibits histamine release induced by ovalbumin in isolated guinea pig lung mast cells. It also inhibits airway obstruction induced by methacholine (acetyl-β-methylcholine; Item No. ) or leukotriene D₄ (LTD₄; Item No. ) in anesthetized guinea pigs. Formulations containing terbutaline have been used in the treatment of asthma.

WARNING This product is not for human or veterinary use.