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Cayman Spinosyn A 17-Pseudoaglycone; Purity- Greater Than Or Equa
List Price
$668.85
Your Price
$668.85
Cayman Spinosyn A 17-Pseudoaglycone; Purity- Greater Than Or Equal To 95%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25530-5
MFG.PART:
25530-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
DNA ligase IV seals double-strand breaks during the process of nonhomologous end-joining in DNA repair. Inhibiting this function in cancer cells is one strategy to prevent deleterious cell growth. SCR7 is a small molecule inhibitor of DNA ligase IV that prevents nonhomologous end-joining by interfering with ligase binding and activating apoptosis. It also inhibits ligase III, but does not affect the activity of T4 DNA ligase or ligase I. SCR7 has been used to increase the rate of homology directed repair triggered by DNA double-strand breaks and to inhibit cancer cell growth in vitro (IC50s = 8-120 µM) and in mouse models when co-administered with double-strand break-inducing therapeutic compounds.,,,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2,3-dihydro-
CAS Number
1533426-72-0
Molecular Formula
C18H14N4OS
Formula Weight
334.4
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/ml
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
- DMSO: 10 mg/ml
- Ethanol: 15 mg/ml
λmax
312, 387 nm
SMILES
O=C(C1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)NC1=N4)NC4=S
InChi Code
InChI=1S/C18H12N4OS/c23-17-15-16(21-18(24)22-17)20-14(12-9-5-2-6-10-12)13(19-15)11-7-3-1-4-8-11/h1-10H,(H2,20,21,22,23,24)
InChi Key
GSRTWXVBHGOUBU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25530-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 25530-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | Australia |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 131929-68-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |