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Cayman Herbimycin C; Purity- Greater Than Or Equal To 98%; Size-
List Price
$1,195.95
Your Price
$1,195.95
Cayman Herbimycin C; Purity- Greater Than Or Equal To 98%; Size- 25 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25485-2.5
MFG.PART:
25485-2.5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
IL-15 is a pro-inflammatory cytokine with roles in cancer and autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, celiac disease, and alopecia areata. IL-15 can induce IL-17 production by CD4 T cells. Y320 is an inhibitor of the release of IL-17 by CD4 T cells stimulated with IL-15, either alone or in combination with CXCL12 and anti-CD3 monoclonal antibody (IC50s = 57.4 and 25.7 nM, respectively). Oral administration of Y320 (0.3-3 mg/kg) reduces the expression of inflammatory cytokines, including IL-17, and inhibits joint destruction in type II collagen-induced arthritis (CIA) in mice. In this model, it acts synergistically with TNF-α monoclonal antibody in ameliorating arthritis and joint destruction scores. Y320 also significantly reduces joint swelling in cynomolgus monkey CIA.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-(4-chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide
CAS Number
288250-47-5
Molecular Formula
C27H29ClN6O2
Formula Weight
505.0
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/ml
- DMF:PBS(pH 7.2)(1:6): 0.1 mg/ml
λmax
222, 287 nm
SMILES
O=C(C1=C(C)N(C2=CC=C(Cl)C=C2)N=C1)NC(C=C3)=CC(C#N)=C3N(CC4)CCC4N5CCOCC5
InChi Code
InChI=1S/C27H29ClN6O2/c1-19-25(18-30-34(19)24-5-2-21(28)3-6-24)27(35)31-22-4-7-26(20(16-22)17-29)33-10-8-23(9-11-33)32-12-14-36-15-13-32/h2-7,16,18,23H,8-15H2,1H3,(H,31,35)
InChi Key
BWZNJVZTAWBIFG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25485-2.5 |
|---|---|
| Featured | No |
| Supplier Part Number | 25485-2.5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | Australia |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 91700-92-4 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |
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