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Cayman 3-Cyano-7-Ethoxycoumarin; Purity- Greater Than Or Equal To
List Price
$363.00
Your Price
$363.00
Cayman 3-Cyano-7-Ethoxycoumarin; Purity- Greater Than Or Equal To 95%; Size- 50 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25441-50
MFG.PART:
25441-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
TNP-ATP is a derivative of ATP and an antagonist at the purinergic receptor subtypes P2X1, P2X3, and P2X2/3 (IC50s = 6, 0.9, and 7 nM, respectively). It is selective for those receptor subtypes over P2X2, P2X4, and P2X7 receptors (IC50s = 2,000, 15,200, and >30,000 nM, respectively). TNP-ATP inhibits calcium flux in 1321N1 cells expressing P2X3 and P2X2/3 receptors (IC50s = 10 and 62 nM, respectively). In a mouse model of visceral pain, TNP-ATP reduces acetic-acid induced writhing with an ED50 value of 6.35 µmol/kg. TNP-ATP is also a fluorescent probe for the activity of ATP-binding enzymes, such as insulin-degrading enzyme (IDE). It displays excitation/emission maxima of 403 and 547 nm, respectively, with a four-fold increase in fluorescence intensity and an emission shift to 538 nm when bound to IDE.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
((3aR,4R,
Molecular Formula
C16H13N8O19P3 • 4C6H16N
Formula Weight
1123.0
Purity
≥95%
Emission
547 nm
Excitation
403 nm
Formulation
A 10 mM solution in water
Solubility
- Water: Soluble
SMILES
O=P(OP(OP(O)([O-])=O)([O-])=O)([O-])OC[C@@H]1[C@]2([H])[C@](OC3(C([N+]([O-])=O)=C/C(C=C3[N+]([O-])=O)=[N+]([O-])/[O-])O2)([H])[C@H](N4C=NC5=C4N=CN=C5N)O1.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC
InChi Code
InChI=1S/C16H16N8O19P3.4C6H15N/c17-13-10-14(19-4-18-13)21(5-20-10)15-12-11(7(39-15)3-38-45(34,35)43-46(36,37)42-44(31,32)33)40-16(41-12)8(23(27)28)1-6(22(25)26)2-9(16)24(29)30;4*1-4-7(5-2)6-3/h1-2,4-5,7,11-12,15H,3H2,(H6-,17,18,19,25,26,31,32,33,34,3
InChi Key
XTSNRUFLZVGKOU-NRBYJGOSSA-O
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-25441-50 |
|---|---|
| Featured | No |
| Supplier Part Number | 25441-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 117620-77-6 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |