Cayman Cp 466,722; Purity- Greater Than Or Equal To 98%; Size- 1

L-732,138 is a neurokinin-1 (NK₁) receptor antagonist (IC₅₀ = 1.6 nM in CHO cells expressing the human receptor). It is selective for NK₁ over NK₂ and NK₃ receptors (IC₅₀s = >5,000 nM for both). L-732,138 inhibits the growth of COLO 858, MEL HO, and COLO 679 melanoma cells (IC₅₀s = 44.6, 76.3, and 64.2 μM, respectively), as well as induces apoptosis in these cell lines. It inhibits plasma extravasation induced by substance P (Item No. ) in guinea pigs (ID₅₀ = 8 mg/kg, i.p.). L-732,138 attenuates mechanical allodynia and cold hyperalgesia in a rat model of neuropathic pain induce by chronic constriction injury of the sciatic nerve.

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