Cayman Alprenolol; Purity- Greater Than Or Equal To 98%; Size- 50

Alprenolol is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT_1A and 5-HT_1B.^1,2 It binds to β₁-, β₂-, and β₃-ARs expressed in CHO cells (K_ds = 15, 0.91, and 117 nM, respectively, for the human receptors) and to 5-HT_1A and 5-HT_1B receptors in rat hippocampal and striatal membranes (K_is = 34 and 134 nM, respectively).^1,2 In vivo, alprenolol (40 mg/kg, i.v.) completely blocks the hyperactivity response of rats to 2-PCPA (Item No. 10010494) and L-tryptophan.³ Alprenolol (10 μg, i.v.) inhibits decreases in heart rate and left ventricular systolic pressure induced by the β₂-AR antagonist ICI 118551 (Item No. 15591) in transgenic mice overexpressing the β₂-AR.⁴ It also reduces the level of abnormal prion fibrils (PrP^Sc) in the brain of mice intracerebrally infected with prion disease to less than 20% of control levels when administered in drinking water at a dose of 50 mg/L.⁵

WARNING This product is not for human or veterinary use.