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Cayman Enalapril-D5 (Maleate); Purity- Greater Than Or Equal To 9
List Price
$86.00
Your Price
$86.00
Cayman Enalapril-D5 (Maleate); Purity- Greater Than Or Equal To 99% Deuterated Forms (D1-D5); Size- 500 Micrograms; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25318-500
MFG.PART:
25318-500
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
EHop-016 is an inhibitor of the small Rho GTPases Rac1 and Rac3. It inhibits Rac1 activity in MDA-MB-435 breast cancer cells with an IC50 value of 1.1 μM in a Rac1 activation assay. At a concentration of 1 μM, EHop-016 inhibits 58% of Rac3 activity, and it inhibits Cdc42 activity but only at higher concentrations (5-10 μM). It also increases Rho GTPase RhoA activity ~1.3-fold at concentrations greater than 2 μM. EHop-016 (2-4 μM) inhibits Rac-regulated functions in MDA-MB-435 cells, including lamellipodia formation and serine/threonine p21-activated kinase 1 (PAK1)-mediated cell migration. In a nude mouse model of breast cancer metastasis, EHop-016 (25 mg/kg) significantly lowers mammary fat pad tumor growth, metastasis, and angiogenesis. It also inhibits mutant receptor tyrosine kinase (KIT)-induced growth in systemic mastocytosis and acute myeloid leukemia (AML) cells (≥2.5 μM).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N4-(9-ethyl-
CAS Number
1380432-32-5
Molecular Formula
C25H30N6O
Formula Weight
430.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/ml
- DMF:PBS (pH 7.2); (1:7): 0.125
- DMSO: 10 mg/ml
λmax
232, 305 nm
SMILES
CCN(C1=C2C=CC=C1)C(C2=C3)=CC=C3NC4=NC(NCCCN5CCOCC5)=NC=C4
InChi Code
InChI=1S/C25H30N6O/c1-2-31-22-7-4-3-6-20(22)21-18-19(8-9-23(21)31)28-24-10-12-27-25(29-24)26-11-5-13-30-14-16-32-17-15-30/h3-4,6-10,12,18H,2,5,11,13-17H2,1H3,(H2,26,27,28,29)
InChi Key
AFTZZRFCMOAFCR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25318-500 |
|---|---|
| Featured | No |
| Supplier Part Number | 25318-500 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 349554-02-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |
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