Cayman Dutasteride-13c6; Purity- Greater Than Or Equal To 98%; Si

5-(N,N-hexamethylene)-Amiloride (HMA) is a derivative of amiloride (Item No. ) with diverse biological activities.^,,,, It is an allosteric antagonist of adenosine A_2A receptors (K_i = 3.3 µM). HMA inhibits the cation-selective ion channel formed by the HIV-1 viral protein Vpu when used at a concentration of 50 µM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu when used at a concentration of 10 µM. It also blocks the cation-selective ion channels formed by the hepatitis C virus (HCV) protein p7. HMA (40 µM) induces necrosis in and reduces the viability of MCF-7, MDA-MB-231, T47D, SK-BR-3, Met-1, and NDL breast cancer cells but not cardiomyocytes or uterine, pulmonary, and renal epithelial cells. HMA protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls.

WARNING This product is not for human or veterinary use.