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Cayman Bibf 1120-13c-D3; Purity- Greater Than Or Equal To 99% Deu
List Price
$751.00
Your Price
$751.00
Cayman Bibf 1120-13c-D3; Purity- Greater Than Or Equal To 99% Deuterated Forms (D1-D3); Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25312-1
MFG.PART:
25312-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
G-749 is an inhibitor of Fms-like tyrosine receptor kinase 3 (FLT3) with IC50 values ranging from 2.1 to 38.1 nM for wild-type and mutant (constitutively active) FLT3s in Ba/F3 cells expressing recombinant receptors. It also inhibits growth of human leukemia cell lines that express FLT3-ITD mutant kinase (IC50s = 3.5 and 7.5 nM for MV4-11 and Molm-14 cells, respectively) but has no effect on cells that lack FLT3 expression or that express wild-type FLT3. G-749 reduces tumor growth and increases survival in a dose-dependent manner in MV4-11 and Molm-14 murine leukemia xenograft models. It reduces growth of bone marrow blasts derived from acute myeloid leukemia patients, showing more potent inhibition of blasts expressing the FLT3-ITD mutant receptor.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
8-bromo-2-[(1-
CAS Number
1457983-28-6
Molecular Formula
C25H25BrN6O2
Formula Weight
521.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 16 mg/ml
- DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml
- DMSO: 3 mg/ml
λmax
261 nm
SMILES
BrC1=CNC(C2=C1N=C(NC3CCN(C)CC3)N=C2NC4=CC=C(OC5=CC=CC=C5)C=C4)=O
InChi Code
InChI=1S/C25H25BrN6O2/c1-32-13-11-17(12-14-32)29-25-30-22-20(26)15-27-24(33)21(22)23(31-25)28-16-7-9-19(10-8-16)34-18-5-3-2-4-6-18/h2-10,15,17H,11-14H2,1H3,(H,27,33)(H2,28,29,30,31)
InChi Key
SXWMIXPJPNCXQQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25312-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 25312-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | Y |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |