Cayman (В±)-Propranolol-D7; Purity- Greater Than Or Equal To 99%

(±)-Propranolol-d₇ is intended for use as an internal standard for the quantification of propranolol (Item Nos. | ) by GC- or LC-MS. (±)-Propranolol is a β-adrenergic receptor (β-AR) antagonist (K_ds = 6.91, 0.832, and 117.49 nM for human β₁-, β₂-, and β₃-ARs, respectively). It reduces mean blood pressure, resting heart rate, and contractility and increases AV conduction time in dogs. (±)-Propranolol restores normal sinus rhythm in dogs with ouabain-induced arrhythmias (ED₅₀ = 3.8 mg/kg). It also acts as a non-specific serotonin receptor antagonist, reducing tranylcypromine/L-tryptophan-induced hyperactivity in rats. Formulations containing (±)-propranolol have been used for the treatment of hypertension, angina pectoris, and cardiac ischemia.

WARNING This product is not for human or veterinary use.