Cayman Flurbiprofen-D3; Purity- Greater Than Or Equal To 99% Deut

Flurbiprofen-d₃ is intended for use as an internal standard for the quantification of flurbiprofen (Item Nos. 70250 | 10004207 | 70255) by GC- or LC-MS. Flurbiprofen is a non-selective COX inhibitor (IC₅₀s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively).¹ In vivo, flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats.² Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg.³ Formulations containing flurbiprofen have been used to manage pain and inflammation associated with arthritis.

WARNING This product is not for human or veterinary use.