Cayman Flurbiprofen-D3; Purity- Greater Than Or Equal To 99% Deut

Euphorbiasteroid is a tricyclic diterpene that has been found in the plant E. lathyris. It inhibits early-stage adipogenesis of 3T3-L1 cells, decreasing intracellular triglyceride accumulation when used at concentrations of 25 and 50 µM. It decreases the expression of Fas, C/EBPα, PPARγ, and SREBP-1c and increases phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-coenzyme A carboxylase (ACC) in 3T3-L1 cells. Euphorbiasteroid inhibits proliferation of HL-60 cells in a concentration-dependent manner, as well as induces apoptosis and increases the expression of Fas and Fas ligand (FasL) and the activity of caspase-3 and caspase-8 in HL-60 cells. It increases P-glycoprotein activity, reverses multi-drug resistance, and restores cytotoxicity of the anticancer agents vinblastine (Item No. ), paclitaxel (Item No. 10461), and doxorubicin (Item No. ) to MES-SA/Dx5 sarcoma cells.

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