We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Ningetinib; Purity- Greater Than Or Equal To 98%; Size- 5
List Price
$186.00
Your Price
$186.00
Cayman Ningetinib; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25233-5
MFG.PART:
25233-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P1 is important for vascular development and lymphocyte maturation, migration, and trafficking. CYM 5442 is a full agonist for S1P1 internalization, phosphorylation, and ubiquitination (EC50 = 1.35 nM). It is ineffective at S1P2, S1P3, S1P4, and S1P5 at concentrations up to 10 µM. CYM 5442 has been found to activate S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 with an EC50 value of 46 nM. At 50 nM, CYM 5442 can induce S1P1-dependent lymphopenia in mice, decreasing B and T cells by 65 and 85%, respectively.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[4-[5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]amino]-ethanol
CAS Number
1094042-01-9
Molecular Formula
C23H27N3O4
Formula Weight
409.5
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 0.25 mg/ml
- DMSO: 0.25 mg/ml
λmax
233, 282, 302 nm
SMILES
CCOC1=C(OCC)C=C(C2=NC(C3=CC=CC4=C3CCC4NCCO)=NO2)C=C1
InChi Code
InChI=1S/C23H27N3O4/c1-3-28-20-11-8-15(14-21(20)29-4-2)23-25-22(26-30-23)18-7-5-6-17-16(18)9-10-19(17)24-12-13-27/h5-8,11,14,19,24,27H,3-4,9-10,12-13H2,1-2H3
InChi Key
NUIKTBLZSPQGCP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25233-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 25233-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1394820-69-9 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |