Cayman Lansoprazole-D4; Purity- Greater Than Or Equal To 99% Deut

Lansoprazole-d₄ is intended for use as an internal standard for the quantification of lansoprazole (Item No. 13627) by GC- or LC-MS. Lansoprazole is a proton pump inhibitor that inhibits the H⁺/K⁺-ATPase.¹ It inhibits K⁺ and H⁺ accumulation in gastric microsomes in a concentration-dependent manner (IC₅₀s = 6.3 and 7 µM, respectively) and inhibits H⁺/K⁺-ATPase activity by approximately 60% when used at a concentration of 10 µM. Lansoprazole inhibits the H⁺/K⁺-ATPase in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.² It is a substituted benzimidazole that binds covalently to proton pumps, providing complete and prolonged inhibition of acid secretion.^3,4 Formulations containing lansoprazole have been used as a proton pump inhibitor and in combination with antibiotics in the treatment of H. pylori infections and duodenal ulcer disease.

WARNING This product is not for human or veterinary use.