Cayman Isosakuranetin; Purity- Greater Than Or Equal To 98%; Size

Oxybutynin is an antagonist of muscarinic acetylcholine receptors (K_is = 5, 14.5, 3.7, 5.3, and 40 nM for human recombinant M_1-5, respectively). It inhibits intracellular calcium mobilization induced by carbamoylcholine (carbachol; Item No. ) in bladder smooth muscle and submandibular gland cells isolated from cynomolgus monkeys (K_is = 2 and 1 nM, respectively). Oxybutynin inhibits volume-induced bladder contraction (VIBC) and oxotremorine-induced salivation (OIS) in rats (ID₅₀s = 0.062 and 0.089 mg/kg, respectively). It also increases pupil diameter (PD) and locomotor activity (LMA; ED₅₀s = 0.29 and 0.52 mg/kg, respectively) and decreases small intestinal transit (SIT; ID₅₀ = 0.22 mg/kg) in rats. Formulations containing oxybutynin have been used in the treatment of overactive bladder.

WARNING This product is not for human or veterinary use.