Cayman Fin56; Purity- Greater Than Or Equal To 98%; Size- 5 Mg

RI-1 is an irreversible inhibitor of RAD51 (IC₅₀s = 5-30 µM), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types.^, RI-1 selectively inhibits homologous recombination without inhibiting single strand annealing. It binds directly to the C319 thiol of RAD51 and inhibits oligomerization of RAD51 filaments. In vitro, RI-1 sensitizes cancer cells to chemotherapeutics that generate interstrand DNA crosslinks, including HEK293 cells co-treated with mitomycin C (LD₅₀ = 16.62 µM).^,

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