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Cayman Unguisin B; Purity- Greater Than Or Equal To 95%; Size- 25
List Price
$683.55
Your Price
$683.55
Cayman Unguisin B; Purity- Greater Than Or Equal To 95%; Size- 25 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25115-2.5
MFG.PART:
25115-2.5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
LDE225 is a smoothened (Smo) antagonist (IC50s = 1.3 and 2.5 nM for mouse and human Smo, respectively). In vivo, LDE225 (20 mg/kg per day) inhibits Gli1 mRNA expression and prevents tumor growth in an orthotopic Ptch+/- p53-/- medulloblastoma mouse allograft model. Formulations containing LDE225 have been used in the treatment of locally advanced basal cell carcinomas.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
rel-N-[6-[(2R,
CAS Number
1218778-77-8
Synonyms
- Erismodegib
- NVP-LDE225
- Sonidegib
Molecular Formula
C26H26F3N3O3 • 2H3PO4
Formula Weight
681.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/ml
- DMSO: 10 mg/ml
- Ethanol: 10 mg/ml
- Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
λmax
276 nm
SMILES
C[C@@H]1CN(C2=NC=C(NC(C3=CC=CC(C4=CC=C(OC(F)(F)F)C=C4)=C3C)=O)C=C2)C[C@H](C)O1.OP(O)(O)=O.OP(O)(O)=O
InChi Code
InChI=1S/C26H26F3N3O3.2H3O4P/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29;2*1-5(2,3)4/h4-13,16-17H,14-15H2,1-3H3,(H,31,33);2*(H3,1,2,3,4)/t16-,17+;;
InChi Key
RWIVSVMMGFFZIJ-VWDRLOGHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25115-2.5 |
|---|---|
| Featured | No |
| Supplier Part Number | 25115-2.5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | Australia |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 226956-07-6 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |