Cayman Kaempferol-3-Glucoside; Purity- Greater Than Or Equal To 9

Kaempferol-3-glucoside is an orally bioavailable flavonoid that has been isolated from the leaves of D. kaki and R. agrestis and has anti-inflammatory activity.^1,2 Kaempferol-3-glucoside (20-80 µg/ml) dose-dependently inhibits IL-1β-stimulated nitric oxide and prostaglandin E₂ (PGE₂; Item No. 14010) production in patient-derived osteoarthritis chondrocytes, an effect that is blocked by the PPAR-γ inhibitor GW 9662 (Item No. 70785).² It also inhibits IL-1β-stimulated expression of nitric oxide synthase (NOS) and COX-2 and activation of MAPK and NF-κB signaling. Kaempferol-3-glucoside (1-20 µM) dose-dependently prevents the loss of E-cadherin, expression of vimentin, and production of collagen type-1 in hydrogen peroxide-exposed human bronchial epithelial cells in vitro.³ Kaempferol-3-glucoside (1.5 mg/kg, p.o.) inhibits ear swelling and the production of IL-2 and IL-4 as well as reduces serum IgE levels in a mouse model of atopic dermatitis.¹ Kaempferol-3-glucoside (10-20 mg/kg, p.o.) also reduces reactive oxygen species (ROS) production, collagen fiber deposition, and autophagosome formation in the epithelial lung tissue of ovalbumin-challenged mice.³

WARNING This product is not for human or veterinary use.