Cayman 3,4-Dicaffeoylquinic Acid; Purity- Greater Than Or Equal T

Chelidonic acid is a pyran that has been found in C. majus and has diverse biological activities.^,, It inhibits rat brain glutamate decarboxylase (K_i = 1.2 μM). Chelidonic acid (20 mg/kg per day) reduces serum IL-6 and TNF-α levels, colonic COX-2 and prostaglandin E₂ (PGE₂; Item No. ) levels, and the disease activity index score in a mouse model of ulcerative colitis induced by dextran sulfate sodium (DSS; Item No. ). It inhibits ovalbumin challenge-induced decreases in spleen IFN-γ levels and increases in serum, spleen, and nasal mucosa IgE levels, spleen IL-4 levels, and nasal mucosa eosinophil and mast cell infiltration in a mouse model of ovalbumin-sensitized allergic rhinitis when administered at a dose of 2 mg/kg.

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