Cayman 15,16-Dihydrotanshinone I; Purity- Greater Than Or Equal T

Bretazenil is a positive allosteric modulator of GABA_A receptors with anticonvulsant and anxiolytic activity. It potentiates GABA-gated chloride currents in rat cortical neurons and in HEK293 cells expressing α₁β₁γ₂ subunit-containing GABA_A receptors (EC₅₀s = 60 and 10 nM, respectively). Bretazenil inhibits binding of the benzodiazepine diazepam to rat cerebral cortex homogenates (IC₅₀ = 2.2 nM). It inhibits tonic convulsions induced by pentylenetetrazol (PTZ; Item No. ) and maximal electroshock (MES) in rats (ED₅₀s = 0.07 and 0.48 mg/kg, respectively). Bretazenil (5-30 mg/kg) increases the number of open arm entries and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.

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