Cayman 15,16-Dihydrotanshinone I; Purity- Greater Than Or Equal T

15,16-Dihydrotanshinone I (DHTS) is a diterpene tanshinone that has been found in the roots of S. miltiorrhiza with diverse biological activities.¹ DHTS inhibits RHL-2H3 mast cell degranulation with an IC₅₀ value of 14.3 μM and reduces the tyrosine phosphorylation of phospholipase Cγ2 (PLCγ2) and ERK.² It prevents HuR binding to RNA in a cell-free assay (K_i = 3.74 nM) and inhibits the production of TNF mRNA and protein in MCF-7 cells.¹ DHTS reduces the viability of MCF-7, MDA-MB-231, and SK-BR-3 breast cancer cells with IC₅₀ values of 0.84, 0.92, and 1.2 μM, respectively. It also reduces collagen-induced aggregation of washed rabbit platelets (IC₅₀ = 8.7 μM).³ In vivo, DHTS (25 mg/kg per day) reduces tumor growth in an HL-60 leukemia mouse xenograft model by 68% relative to control without decreasing body weight.⁴ In mice with scopolamine-induced learning and memory impairment, DHTS (2-4 mg/kg, p.o.) increases latency to step-through in a passive avoidance test by approximately 3- to 4-fold, and it inhibits acetylcholinesterase in brain homogenate (IC₅₀ = 25 μM).⁵

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