We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Aconine; Purity- Greater Than Or Equal To 95%; Size- 10 Mg
List Price
$350.00
Your Price
$350.00
Cayman Aconine; Purity- Greater Than Or Equal To 95%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25048-10
MFG.PART:
25048-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
MSC2530818 is an orally bioavailable cyclin-dependent kinase 8 (Cdk8) inhibitor (IC50 = 2.6 nM). It is selective for Cdk8 over a panel of 264 kinases at 1 µM but does inhibit glycogen synthase kinase 3α (GSK3α; IC50 = 691 nM). MSC2530818 inhibits STAT1 phosphorylation in SW620 colorectal cancer cells with an IC50 value of 8 nM. It also inhibits Wnt-dependent transcription in LS 174T, COLO 205, and PA-1 cancer cells (IC50s = 32, 9, and 52 nM, respectively, in luciferase reporter assays). MSC2530818 (50 and 100 mg/kg) reduces tumor growth in a SW620 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
[(2S)-2-(4-
CAS Number
1883423-59-3
Molecular Formula
C18H17ClN4O
Formula Weight
340.8
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml
- DMSO: 15 mg/ml
- Ethanol: 10 mg/ml
λmax
223 nm
SMILES
CC1=NNC2=NC=C(C(N3CCC[C@@]3([H])C4=CC=C(Cl)C=C4)=O)C=C21
InChi Code
InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16(23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/m0/s1
InChi Key
ODRITQGYYWHQGM-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25048-10 |
|---|---|
| Featured | No |
| Supplier Part Number | 25048-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 509-20-6 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |
Write Your Own Review