Cayman Ezetimibe-D4; Purity- Greater Than Or Equal To 99% Deutera

Ezetimibe-d₄ is intended for use as an internal standard for the quantification of ezetimibe (Item No. ) by GC- or LC-MS. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes.^, Upon oral administration ezetimibe undergoes rapid glucuronidation in the intestine where its glucuronide binds NPC1L1.^, Ezetimibe exhibits ED₅₀ values of 0.0005-0.05 mg/kg in various animal models, selectively blocking cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen, affecting bile acid micelle solubilization of cholesterol, or interfering with the absorption of triglycerides, fatty acids, or bile acids.^,

WARNING This product is not for human or veterinary use.