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Cayman Tadalafil-D3; Purity- Greater Than Or Equal To 99% Deutera
List Price
$178.00
Your Price
$178.00
Cayman Tadalafil-D3; Purity- Greater Than Or Equal To 99% Deuterated Forms (D1-D3); Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25030-1
MFG.PART:
25030-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Reparixin is a non-competitive allosteric inhibitor of the activation of CXCR1 and CXCR2 chemokine receptors by IL-8 (IC50s = 1 and 100 nM, respectively). It blocks a range of activities related to IL-8 signaling, including leukocyte recruitment (IC50 = 1 nM) and other inflammatory responses, without affecting receptor activation induced by other CXCR1 and CXCR2 agonists. In spontaneously hypertensive rats, 5 mg/kg reparixin administered daily for three weeks reduces blood pressure by inhibiting hypertension-related mediators, IL-8, 12-lipoxygenase, and endothelin-1. Reparixin blockade (100 nM) of CXCR1 depletes a cancer stem cell population in human breast cancer cell lines in vitro.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(αR)-α-methyl-
CAS Number
266359-93-7
Synonyms
- Repertaxin
Molecular Formula
C14H21NO3S • C6H14N2O2
Formula Weight
429.6
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: slightly soluble
- DMSO: 10 mg/ml
- Ethanol: slightly soluble
- PBS (pH 7.2): 10 mg/ml
λmax
202 nm
SMILES
CS(NC([C@H](C)C1=CC=C(CC(C)C)C=C1)=O)(=O)=O.OC([C@@H](N)CCCCN)=O
InChi Code
InChI=1S/C14H21NO3S.C6H14N2O2/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18;7-4-2-1-3-5(8)6(9)10/h5-8,10-11H,9H2,1-4H3,(H,15,16);5H,1-4,7-8H2,(H,9,10)/t11-;5-/m10/s1
InChi Key
JEJFWWFZAQBZMJ-GVKMLHTLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25030-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 25030-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 960226-55-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |