Cayman Incb024360 Analog; Purity- Greater Than Or Equal To 98%; S

Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD⁺ via the kynurenine pathway. It has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. INCB024360 analog is a potent IDO1 inhibitor that demonstrates IC₅₀ values of 67 and 19 nM for human IDO in enzymatic activity and HeLa cell assays, respectively.^,, It is inactive against tryptophan 2,3-dioxygenase (IC₅₀ > 10 µM). At 25-75 mg/kg, subcutaneous administration of INCB024360 analog to mice significantly decreased kynurenine levels in plasma and dose-dependently reduced the growth of GM-CSF-secreting B16 tumor xenografts. A fluorine-18 moiety has been used to label this compound for use as a probe for imaging IDO1 expression via positron emission tomography.

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