Cayman Xanthine Oxidase Horseradish Peroxidase; Size- 1 Ea

α,β-Methyleneadenosine 5-triphosphate (αβ-methylene ATP) is a phosphonic analog of ATP that is characterized by the replacement of the bridging oxygen atom between the α- and β-phosphate groups with methylene. It is an agonist of P2X purinoceptors P2X₁ and P2X₃ (EC₅₀ = ~1 µM) and is ~1,000-fold less potent at P2X₂, P2X receptors 4-7, and P2Y receptors.^,,, Persistent activation of purinoceptors results in desensitization, resulting in an antagonist-like effect of αβ-methylene ATP. αβ-methylene ATP is used as a stable analog of ATP (Item No. ) to study the interaction of ATP with kinases and other proteins.^, It weakly binds and inhibits adenylate cyclase in a calcium-dependent manner (K_i= ~0.5 mM).^,

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