Cayman Pargyline (Hydrochloride); Purity- Greater Than 98%; Size-

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO; K_is = 15 and 1.8 μM for MAO-A and MAO-B, respectively). At 10 mg/kg i.v., pargyline induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Dawley rats. The correlation between the fall of blood pressure and the inhibition of brain MAO suggests that the accumulation of amine in brain is responsible for the fall in pressure. Reactive oxygen species-mediated monocyte hypertrophy is prevented by pargyline at a concentration of 10 µM. Formulations containing pargyline have been used to treat moderate hypertension.^,

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