Cayman N-Cyclohexanecarbonylpentadecylamine; Purity- Greater Than

Numerous analogs of fatty acyl ethanolamides potentiate the intrinsic biological activity of endocannabinoids.¹ This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty acid amide hydrolase (FAAH) within the neurons. ² However, Ueda has recently cloned another amidase, the acidic palmitoyl ethanolamidase (PEAase) that promotes the hydrolysis of palmitoylethanolamide.³ N-Cyclohexanecarbonylpentadecylamine is a selective inhibitor of acidic PEAase, inhibiting the enzyme with an IC₅₀ of 4.5 µM, while failing to inhibit FAAH even at 100 µM.⁴

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