Cell Signaling Cytochrome C Antibody

Name: Cell Signaling Cytochrome C Antibody
SKU: CSIG-4272T
Price: 132.31 USD

List Price $132.31 Your Price $132.31

Cell Signaling Cytochrome C Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-4272T

MFG.PART: 4272T

UNSPSC: 12352202

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	H M R Mk Dm
Sensitivity	Endogenous
Molecular Weight (kDa)	14
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunohistochemistry (Paraffin): 1:200}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Cytochrome c Antibody detects endogenous levels of cytochrome c protein.
Species Reactivity	Human, Mouse, Rat, Monkey, D. melanogaster
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro72 of human cytochrome c. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Cytochrome c is a well conserved electron-transport protein and is part of the respiratory chain localized to mitochondrial intermembrane space (1). Upon apoptotic stimulation, cytochrome c released from mitochondria associates with procaspase-9 (47 kDa)/Apaf 1. This complex processes caspase-9 from inactive proenzyme to its active form (2). This event further triggers caspase-3 activation and eventually leads to apoptosis (3).

Specifications