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Millipore The P38/Sapk2 Inhibitor (Sb 203580) Controls The Biological Activity Of P38/Sapk2. This Small Molecule/Inhibitor Is Primarily Used For Biochemicals Applications. - Mill (Additional S&H or Hazmat Fees May Apply)
The p38/SAPK2 Inhibitor (SB 203580) controls the biological activity of p38/SAPK2. This small molecule/inhibitor is primarily used for Biochemicals applications.
Key Applications
Kinase Assay
Application Notes
Highly specific inhibitor of p38/SAPK2
Biological Information
Entrez Gene Number
NM_002751.5
Entrez Gene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
Gene Symbol
MAPK11
p38-2
p38b
P38B
p38Beta
p38beta2
SAPK2B
SAPK2
PRKM11
P38BETA2
Protein Target
p38/SAPK2
Target Sub-Family
CMGC
UniProt Number
Q15759
UniProt Summary
FUNCTION: SwissProt: Q15759 # Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2. COFACTOR: Magnesium (By similarity). SIZE: 364 amino acids; 41357 Da TISSUE SPECIFICITY: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas. DOMAIN:SwissProt: Q15759 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme (Probable). SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
Product Usage Statements
Quality Assurance
Routinely evaluated in a kinase assay.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
