Key Specifications Table
| Uni Prot Number |
|---|
| Q15759 |
| Description | |
|---|---|
| Catalogue Number | 19-134 |
| Brand Family | Upstate |
| Trade Name |
|
| Description | p38/SAPK2 Inhibitor (SB 202190) |
| Product Information | |
|---|---|
| Presentation | C20H14FN3O |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | The p38/SAPK2 Inhibitor (SB 202190) controls the biological activity of p38/SAPK2. This small molecule/inhibitor is primarily used for Biochemicals applications. |
| Key Applications |
|
| Application Notes | Potent inhibitor of p38 alpha/SAPK2a and p38 beta/SAPK2b kinases. |
| Biological Information | |
|---|---|
| Entrez Gene Number |
|
| Entrez Gene Summary | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. |
| Gene Symbol |
|
| Protein Target | p38/SAPK2 |
| Target Sub-Family | CMGC |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: Q15759 # Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2. COFACTOR: Magnesium (By similarity). SIZE: 364 amino acids; 41357 Da TISSUE SPECIFICITY: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas. DOMAIN:SwissProt: Q15759 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme (Probable). SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Routinely evaluated in a kinase assay as an inhibitor. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | 3 years at -20°C |
| Packaging Information | |
|---|---|
| Material Size | 1 mg |