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GCN2 (EIF2AK4) belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1) to downregulate protein synthesis in response to varied cellular stresses.
N-terminal GST-tagged, recombinant, human GCN2 full length, expressed by baculovirus in Sf21 insect cells. The recombinant protein contains the amino acid substitution E556G with reference to GenPept NP_001013725. E556G is reported in GenPept CAH10626.
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NP_001013725
Gene Symbol
GCN2
EIF2AK4
KIAA1338
Protein Target
Not Applicable
Purification Method
Purified using glutathione sepharose.
Target Sub-Family
STE
UniProt Number
Q9P2K8
Molecular Weight
215 kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by phosphorylation of peptide RSRSRSRSRSRSRSR
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
