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CLK1 is a dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.
N-terminal 6His-tagged, recombinant, human CLK1, amino acids 130-end expressed by baculovirus in Sf21 insect cells
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_004071
Gene Symbol
CLK1
CLK
STY
Purification Method
Purified using immobilized metal affinity chromatography.
Target Sub-Family
CMGC
UniProt Number
P49759
Molecular Weight
45 kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by phosphorylation of peptide ERMRPRKRQGSVRRRV
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
6 months at -70°C
Packaging Information
Material Size
10 µg
Material Package
Also available in 250μg size as catalog # 14-920M and in bulk as catalog # 14-920-K.
