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Millipore Active, N-Terminal 6his-Tagged, Recombinant, Human Itk, Amino Acids 352-617. For Use In Kinase Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
N-terminal 6His-tagged, recombinant, human Itk, amino acids 352-617.
Product Information
Quality Level
MQ100
Applications
Application
Active, N-terminal 6His-tagged, recombinant, human Itk, amino acids 352-617. For use in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Source
Human Itk expressed by baculovirus in Sf21 cells.
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_005546.3
Entrez Gene Summary
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
Gene Symbol
ITK
LYK
PSCTK2
EMT
MGC126258
MGC126257
Protein Target
Itk
Purification Method
Ni2+/NTA-agarose
Target Sub-Family
TK
UniProt Number
Q08881
UniProt Summary
FUNCTION: SwissProt: Q08881 # Plays a role in T-cell proliferation and differentiation. COFACTOR: Binds 1 zinc ion per subunit (By similarity). SIZE: 620 amino acids; 71831 Da SUBCELLULAR LOCATION: Cell membrane (By similarity). Note=Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T- cells (By similarity). TISSUE SPECIFICITY: T-cell lines and natural killer cell lines. SIMILARITY: SwissProt: Q08881 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. & Contains 1 Btk-type zinc finger. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
Molecular Weight
34kDa
Product Usage Statements
Quality Assurance
routinely evaluated by phosphorylation of MBP.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
