The store will not work correctly when cookies are disabled.
We use cookies to make your experience better.To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Millipore Active Complex Of N-Terminal His6-Tagged Recombinant, Full-Length, Human P110δ & Untagged, Recombinant, Full Length, Human P85α. For Use In Kinase Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
Complex of N-terminal His6-tagged recombinant, full-length, human p110δ and untagged, recombinant, full length, human p85α
Product Information
Quality Level
MQ100
Applications
Application
Active complex of N-terminal His6-tagged recombinant, full-length, human p110δ & untagged, recombinant, full length, human p85α. For use in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Source
Coexpressed by baculovirus in Sf21 insect cells
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_005026.2
Entrez Gene Summary
Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras.[supplied by OMIM]
Gene Symbol
PIK3CD
p110d
PI3K
p110D
p110delta
Protein Target
PI3Kδ/p85α
Purification Method
Ni2+/NTA-agarose
Target Sub-Family
PI3K/PI4K
UniProt Number
O00329
UniProt Summary
SIZE: 1044 amino acids; 119479 Da SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Interacts with ERAS (By similarity). TISSUE SPECIFICITY: Expressed predominantly in leukocytes. PTM: Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity. SIMILARITY: SwissProt: O00329 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
Molecular Weight
P110δ (121.6kDa) & p85α (83.7kDa)
Product Usage Statements
Quality Assurance
routinely evaluated by the PIProfiler™
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
6 months at -70°C
Packaging Information
Material Size
10 µg
Material Package
Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-604M when ordering the 250μg size.
