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Millipore Active Complex Of N-Terminal His6-Tagged Recombinant Full-Length Human P110β & Untagged, Recombinant, Full Length, Human P85&Alpha. For Use In Kinase Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
Complex of N-terminal His6-tagged recombinant full-length human p110β and untagged, recombinant, full length, human p85&alpha
Product Information
Quality Level
MQ100
Applications
Application
Active complex of N-terminal His6-tagged recombinant full-length human p110β & untagged, recombinant, full length, human p85&alpha. For use in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Source
Coexpressed by baculovirus in Sf21 insect cells
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_006219.1
Entrez Gene Summary
Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993 [PubMed 8246984]).[supplied by OMIM]
Gene Symbol
PIK3CB
DKFZp779K1237
PI3K
p110-BETA
PI3Kbeta
MGC133043
PIK3C1
Protein Target
PI3Kβ/p85α
Purification Method
Ni2+/NTA-agarose
Target Sub-Family
PI3K/PI4K
UniProt Number
P42338
UniProt Summary
FUNCTION: SwissProt: P42338 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2. SIZE: 1070 amino acids; 122762 Da SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. TISSUE SPECIFICITY: Expressed ubiquitously. SIMILARITY: SwissProt: P42338 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
Molecular Weight
p110β (124kDa) & p85&alpha (83.7kDa)
Product Usage Statements
Quality Assurance
routinely evaluated in a 30 minute reaction using the PIProfiler™ protocol (see www.upstate.com/features/piprofiler).
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
6 months at -70°C
Packaging Information
Material Size
20 µg
Material Package
Also available in 250μg size as catalog # 14-603M - Call for pricing and availability.
