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Millipore Active Complex Of N-Terminal His6-Tagged Recombinant Full-Length Human P110α & Untagged, Recombinant, Full Length, Human P85α. For Use In Kinase Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
Complex of N-terminal His6-tagged recombinant full-length human p110α and untagged, recombinant, full length, human p85α
Product Information
Quality Level
MQ100
Applications
Application
Active complex of N-terminal His6-tagged recombinant full-length human p110α & untagged, recombinant, full length, human p85α. For use in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Source
Coexpressed by baculovirus in Sf21 insect cells
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_006218.2
Entrez Gene Summary
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
Gene Symbol
PIK3CA
PI3K
MGC142161
p110-alpha
MGC142163
Protein Target
PI3Kα/p85α
Purification Method
Ni2+/NTA-agarose
Target Sub-Family
PI3K/PI4K
UniProt Number
P42336
UniProt Summary
FUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2. SIZE: 1068 amino acids; 124284 Da SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity). DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370]. SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.
Molecular Weight
p110α (125.3kDa) & p85α (83.7kDa)
Product Usage Statements
Quality Assurance
routinely evaluated by PIProfiler
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
6 months at -70°C
Packaging Information
Material Size
20 µg
Material Package
Also available in 250μg size as catalog # 14-602M - Call for pricing and availability.
