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Millipore Active Complex Of Recombinant Full Length Human Cdk5 Containing & N-Terminal His6-Tag & Recombinant Full-Length Human P35 Containing An N-Terminal Gst-Tag, For Use In Kinase Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
Complex of recombinant fulllength human cdk5 containing and N-terminal His6-tag and recombinant full-length human p35 containing an N-terminal GST-tag
Product Information
Quality Level
MQ100
Applications
Application
Active complex of recombinant full length human Cdk5 containing & N-terminal His6-tag & recombinant full-length human p35 containing an N-terminal GST-tag, for use in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Source
Both are expressed by baculovirus in Sf21 insect cells
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_004935.2
Gene Symbol
CDK5
PSSALRE
Protein Target
CDK5/p35
Purification Method
Ni-NTA agarose
Target Sub-Family
CMGC
UniProt Number
Q00535
UniProt Summary
FUNCTION: SwissProt: Q00535 # Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase. SIZE: 292 amino acids; 33304 Da SUBUNIT: Heterodimer of a catalytic subunit and a regulatory subunit (p35). Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 (By similarity). Interacts with AATK. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, growth cone (By similarity). Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity). SIMILARITY: SwissProt: Q00535 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
Molecular Weight
34kDa (cdk5), 61kDa (p35 with GST-tag)
Product Usage Statements
Quality Assurance
routinely evaluated by phosphorylation of Histone H1
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
1 year at -70°C
Packaging Information
Material Size
10 µg
Material Package
Also available in 250μg size as catalog # 14-477M - Call for pricing and availability.
