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GST fusion-protein, corresponding to Ras Binding Domain of Raf-1, provided bound to glutathione agarose.
Product Information
Quality Level
MQ100
Applications
Key Applications
Enzyme Assays
Biological Information
Source
Human Ras Binding Domain (RBD, residues 1-149) of Raf-1, expressed in E. coli.
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_001085049.1
NM_012219.3
Entrez Gene Summary
Members of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors.[supplied by OMIM]
Gene Symbol
MRAS
RRAS3
M-RAS
FLJ42964
R-RAS3
M-RAs
UniProt Number
O14807
UniProt Summary
FUNCTION: SwissProt: O14807 # May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway. SIZE: 208 amino acids; 23846 Da SUBUNIT: Interacts with RGL3 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). TISSUE SPECIFICITY: Expression highly restricted to the brain and heart. SIMILARITY: SwissProt: O14807 ## Belongs to the small GTPase superfamily. Ras family.
Product Usage Statements
Quality Assurance
Routinely evaluated by Affinity Precipitation/Immunoblot Analysis
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
