| Description | |
|---|---|
| Catalogue Number | 12-243 |
| Brand Family | Upstate |
| Trade Name |
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| Description | S6 Kinase/Rsk2 Substrate Peptide 2 |
| Product Information | |
|---|---|
| Presentation | Lyophilized powder |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | S6 Kinase/Rsk2 Substrate Peptide 2 primarily used in Kinase Assays. |
| Key Applications |
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| Biological Information | |
|---|---|
| Entrez Gene Number |
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| Entrez Gene Summary | This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). |
| Gene Symbol |
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| Protein Target | Rsk2 |
| Target Sub-Family | AGC |
| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: P51812 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. COFACTOR: Magnesium (By similarity). SIZE: 740 amino acids; 83736 Da SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). TISSUE SPECIFICITY: Expressed in many tissues, highest levels in skeletal muscle. PTM: Autophosphorylated on Ser-386, as part of the activation process (By similarity). & Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369 (By similarity). DISEASE: SwissProt: P51812 # Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations. SIMILARITY: SwissProt: P51812 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Routinely evaluated as a substrate for p90 Rsk-2 and p70 S6 Kinase. |
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Lyophilized: Stable for 2 years at -20°C |
| Packaging Information | |
|---|---|
| Material Size | 1 mg |